1. Structural insights into the mechanism of GTP initiation of microtubule ...
25 sep 2023 · Here, we present cryo-EM structures of tubulin heterodimer at their GTP- and GDP-bound states, intermediate assembly states of GTP-tubulin, and ...
In eukaryotes, the dynamic assembly of microtubules (MT) plays an important role in numerous cellular processes. The underlying mechanism of GTP triggering MT assembly is still unknown. Here, we present cryo-EM structures of tubulin heterodimer at their GTP- and GDP-bound states, intermediate assembly states of GTP-tubulin, and final assembly stages of MT. Both GTP- and GDP-tubulin heterodimers adopt similar curved conformations with subtle flexibility differences. In head-to-tail oligomers of tubulin heterodimers, the inter-dimer interface of GDP-tubulin exhibits greater flexibility, particularly in tangential bending. Cryo-EM of the intermediate assembly states reveals two types of tubulin lateral contacts, “Tube-bond” and “MT-bond”. Further, molecular dynamics (MD) simulations show that GTP triggers lateral contact formation in MT assembly in multiple sequential steps, gradually straightening the curved tubulin heterodimers. Therefore, we propose a flexible model of GTP-initiated MT assembly, including the formation of longitudinal and lateral contacts, to explain the nucleation and assembly of MT. In this study the authors explore the enigma of GTP-triggered microtubule assembly. The proposed flexible model emphasizes longitudinal and lateral contacts, enhancing our understanding of microtubule nucleation and assembly.
2. [PDF] State budget borrowing requirements' financing plan and its background
29 mrt 2023 · In the final quarter of 2022 GDP declined by. 2.4% (qoq, sa) after a 1% growth in the previ- ous quarter. Household consumption was.
3. Passive Smoking Indicators in Italy: Does the Gross Domestic Product ...
18 sep 2018 · Background: The aim of this study is to analyse the correlation between regional values of Gross Domestic Product (GDP) and passive smoking ...
Background: The aim of this study is to analyse the correlation between regional values of Gross Domestic Product (GDP) and passive smoking in Italy. Methods: The outcome measures were smoking ban respect in public places, workplaces and at home, derived ...
4. 1. Gross domestic product (GDP) - OECD Statistics
Bevat niet: e155 | Resultaten tonen met:e155
OECD.Stat enables users to search for and extract data from across OECD’s many databases.
5. Predictive Analytics in Focus | Moody's Events
E155. Debt Isn't Everything. 01:20:33. E154. Jobs Survey Smackdown! 48:38. E153 ... Gangbuster GDP. 48:38. E134. Bonds, Baseball and Blankies. 01:21:39. E133.
Your resource for timely economic insights, credit trends, and emerging credit risk management techniques, designed to help you address market challenges and enable better faster decisions.
6. Is GDP the wrong yardstick for measuring prosperity? - WABE
Gross domestic product, the total dollar value of goods and services sold in the U.S., has become fundamental to American economic policy.
Amplifying Atlanta
7. [PDF] Long-term Growth Model Natural Resource Extension (LTGM-NR)
8 mrt 2022 · ... E155]. Part 5: Set paths for exogenous variables: Natural ... Choose GDP Per Capita Annual growth rate from the dropdown menu in Cell A38.
8. Channel 11: Good Times Bad Times - DoubleLine
4 mrt 2024 · Shinoda concludes with a review of economist forecasts for inflation and GDP ... Using Fed Funds Probabilities – with a Grain of Salt (E155).
DoubleLine Portfolio Manager Ken Shinoda takes a look at the state of the markets and macro issues in his recap of February in addition to the economic outlook going forward, a potentially mixed bag summed up by the title of Led Zeppelin’s 1969 song “Good Times Bad Times.” He begins with a look at fixed […]
9. Trend of Mortality Due to Congenital Anomalies in Children Younger ...
3 jun 2024 · Objective: We conducted this study to understand the death burden and trend of under-5 CA mortality (CAMR) in Zhejiang, one of the provinces ...
Background: As one of the leading causes of child mortality, deaths due to congenital anomalies (CAs) have been a prominent obstacle to meet Sustainable Development Goal 3.2. Objective: We conducted this study to understand the death burden and trend of under-5 CA mortality (CAMR) in Zhejiang, one of the provinces with the best medical services and public health foundations in Eastern China. Methods: We used data retrieved from the under-5 mortality surveillance system in Zhejiang from 2012 to 2021. CAMR by sex, residence, and age group for each year was calculated and standardized according to 2020 National Population Census sex- and residence-specific live birth data in China. Poisson regression models were used to estimate the annual average change rate (AACR) of CAMR and to obtain the rate ratio between subgroups after adjusting for sex, residence, and age group when appropriate. Results: From 2012 to 2021, a total of 1753 children died from CAs, and the standardized CAMR declined from 121.2 to 62.6 per 100,000 live births with an AACR of –9% (95% CI –10.7% to –7.2%; P<.001). The declining trend was also observed in female and male children, urban and rural children, and neonates and older infants, and the AACRs were –9.7%, –8.5%, –8.5%, –9.2%, –12%, and –6.3%, respectively (all P<.001). However, no significant reduction was observed in children aged 1-4 years (P=.22). Generally, the CAMR rate ratios for male versus female children, rural versus urban children, olde...
10. Structural insights of the elongation factor EF-Tu complexes in protein ...
3 okt 2022 · Here, we report the crystal structures of Mtb EF-Tu•EF-Ts and EF-Tu•GDP complexes, showing the molecular basis of EF-Tu's representative ...
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu could be an excellent target for treating Mtb infection. Here, we report the crystal ...
11. E155: In conversation with Tucker Carlson, plus OpenAI chaos ...
1 dec 2023 · E155: In conversation with Tucker Carlson, plus OpenAI chaos explained ... E89: GDP growth negative in Q2, $SHOP layoffs, Alzheimer's fraud ...
(0:00) Bestie intros! Tucker Carlson joins the show (0:59) Tucker's departure from Fox News (10:49) The state of American society and the importance of rediscovering national alignment (30:53) Why prosperity begets self-destruction, climate change, immigration (59:48) Thoughts on the current political landscape and presidential candidates (1:09:13) Media control, the importance of free speech platforms, Tucker's future, reacting to Elon's viral moment at the NYT's DealBook Summit (1:33:56) Post-interview debrief (1:41:49) Understanding the chaos at OpenAI Follow the besties: https://twitter.com/chamath https://twitter.com/Jason https://twitter.com/DavidSacks https://twitter.com/friedberg Follow Tucker: https://twitter.com/TuckerCarlson Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg Intro Video Credit: https://twitter.com/TheZachEffect Referenced in the show: Tucker Carlson segment links: https://twitter.com/talkrealopinion/status/1728139279019188257 https://twitter.com/greg_price11/status/1729991837958414573 https://twitter.com/hansmahncke/status/1730019598064390597 OpenAI segment links: https://openai.com/blog/sam-altman-returns-as-ceo-openai-has-a-new-initial-board https://twitter.com/btaylor/status/1730030765482938521 https://twitter.com/chamath/status/1726351777581449627 https://www.reuters.com/technology/sam-altmans-ouster-openai-was-precipitated-by-letter-board-...
12. A national stratification of the global macroeconomic burden of central ...
21 okt 2022 · nomic data in the form of gross domestic product (GDP) and GDP per ... 2020; 22(2): E147-E155. 27. Robinson LA, Hammitt JK, O'Keeffe L ...
13. [PDF] CONGRESSIONAL RECORD— Extensions of Remarks E155 HON ...
E155. February 7, 2020 participation on many committees, task forces, ... D.C. has a higher per capita per- sonal income and gross domestic product than.
14. Is governance, gross domestic product, inequality, population size or ...
31 okt 2017 · index.; GDP, gross domestic product; SII, slope index of inequality ... Pediatrics 2014;134:e155. 1–e1559. 12. Lin RT, Chien LC, Chen YM, et ...
15. [PDF] 1 RED – July/August 2021 - Central Bank of Eswatini
20 aug 2021 · Economic activity as measured by the Gross Domestic Product (GDP) is estimated to ... Alongside bond maturities amounting to E155 million, during ...
16. Use of the input-output model for environmental footprint analysis in ...
23 mei 2022 · The amount of greenhouse gas emissions per unit of gross domestic product ... PEF E155. Language: English. Moderator: prof. Ing. Lukáš Čechura, Ph ...
Workshop - Use of the input-output model for environmental footprint analysis in food production - 13. 6. 2022.
17. ELPEN to invest €155 mln by 2025 | eKathimerini.com
19 jan 2023 · Greek pharmaceuticals manufacturer ELPEN will have completed investments of 155 million euros by the end of 2025 in production and research ...
Greek pharmaceuticals manufacturer ELPEN will have completed investments of 155 million euros by the end of 2025 in production and research facilities with a total area of 55,000 sq.m., said the vice president of ELPEN Pharmaceutical and co-CEO of ELPEN Group, Theodoros Tryfon, on Tuesday.
18. [PDF] report - Georgia Center For Opportunity
Appendix E154: Arkansas State Real GDP ARIMA Model Forecast. 408. Appendix E155: California State Real GDP ARIMA Model Forecast. 410. Appendix E156: Colorado ...
19. [EPUB] Exploring the Role of Public Expenditure in Advancing Female ...
... (GDP).47 The strongest performers among high-income PISA participating ... e155–e164: March 2014. 135 Nwankwo, Ugonma, Megan O'Donnell, and Charles Kenny ...
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20. Cyprus records half-year surplus of €155.5 million
1 aug 2023 · Cyprus has recorded a fiscal surplus of €155.5 million, equivalent to 0.5 per cent of GDP, during the first half of 2023, according to the ...
Cyprus has recorded a fiscal surplus of €155.5 million, equivalent to 0.5 per cent of GDP, during the first half of 2023, according to the latest preliminary results, released on Monday by the state’s statistical service. This marks a notable improvement compared to the same period in 2022 when Cyprus…
21. [PDF] Environmental Fiscal Reform and the Double Dividend
13 feb 2018 · ... E155,808 million from public institutions to households. Cells should ... enterprises to government and GDP is gross domestic product. On the ...
22. Principles and Framework for eHealth Strategy Development
30 jul 2013 · J Med Internet Res 2013;15(7):e155 doi:10.2196/jmir.2250. Keywords. eHealth ... GDP: gross domestic product. HIS: health information system. HIT ...
Significant investment in eHealth solutions is being made in nearly every country of the world. How do we know that these investments and the foregone opportunity costs are the correct ones? Absent, poor, or vague eHealth strategy is a significant barrier to effective investment in, and implementation of, sustainable eHealth solutions and establishment of an eHealth favorable policy environment. Strategy is the driving force, the first essential ingredient, that can place countries in charge of their own eHealth destiny and inform them of the policy necessary to achieve it. In the last 2 years, there has been renewed interest in eHealth strategy from the World Health Organization (WHO), International Telecommunications Union (ITU), Pan American Health Organization (PAHO), the African Union, and the Commonwealth; yet overall, the literature lacks clear guidance to inform countries why and how to develop their own complementary but locally specific eHealth strategy. To address this gap, this paper further develops an eHealth Strategy Development Framework, basing it upon a conceptual framework and relevant theories of strategy and complex system analysis available from the literature. We present here the rationale, theories, and final eHealth strategy development framework by which a systematic and methodical approach can be applied by institutions, subnational regions, and countries to create holistic, needs- and evidence-based, and defensible eHealth strategy and to ensure wi...
23. [PDF] CBE QUARTERLY REVIEW Q2 JUNE 2022 - Central Bank of Eswatini
3 sep 2022 · ... GDP figures are based on GDP projections from the MFT September 2022 review. ... E155.5 million in the quarter ending June 2022, 6.6 per cent ...
24. [PDF] Financial development convergence: New evidence for the EU - EconStor
13 mei 2017 · liabilities to GDP, stock market capitalization to GDP and stock ... 141e155. Caselli, F., Esquivel, G., Lefort, F., 1996. Reopening the ...
25. Cyprus records half-year surplus of e155. 5 million - Paphos Life
1 aug 2023 · Tue Aug 01, 2023 5:52 am. Cyprus has recorded a fiscal surplus of €155. 5 million, equivalent to 0. 5 per cent of GDP, during the first ...
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